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Issue 42, 2015
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The development of a short route to the API ropinirole hydrochloride

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Abstract

A four-step, three-stage synthesis of the API ropinirole hydrochloride has been developed from a commercially available naphthalene derivative. The new route has half the step-count and twice the overall yield of the current manufacturing process. Key features of the synthesis are a regioselective Birch reduction and an ozonolysis with concomitant ring closure to induce the required ring contraction.

Graphical abstract: The development of a short route to the API ropinirole hydrochloride

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Publication details

The article was received on 19 Aug 2015, accepted on 28 Aug 2015 and first published on 28 Aug 2015


Article type: Paper
DOI: 10.1039/C5OB01739D
Author version available: Download Author version (PDF)
Citation: Org. Biomol. Chem., 2015,13, 10532-10539
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    The development of a short route to the API ropinirole hydrochloride

    Z. Yousuf, A. K. Richards, A. N. Dwyer, B. Linclau and D. C. Harrowven, Org. Biomol. Chem., 2015, 13, 10532
    DOI: 10.1039/C5OB01739D

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