Synthesis of quinazolinimines and quinazolinamines from 2-fluorobenzonitriles under catalyst-free conditions

Abstract

A convenient procedure for the synthesis of quinazolinimines and quinazolinamines from 2-fluorobenzonitriles has been developed. By using KO^tBu as the promotor with 2-aminopyridines or amidines as the reaction partner, the desired heterocycles were produced in moderate to good yields under catalyst-free conditions.