Jump to main content
Jump to site search

Issue 43, 2015
Previous Article Next Article

Synthesis and stability of cyclic α-hydrogen nitroxides

Author affiliations


Nitroxides (nitroxyl radicals) hold a unique place in science due to their stable radical nature. We have recently reported the first design concept providing a general solution to the problem of designing and preparing monocyclic α-hydrogen nitroxides. The initial studies were limited to aryl derivatives. We now report a wider study showing that alkyl substituents may be employed as well. In addition, we report several additional examples of aryl substituents and reveal some of the structural limitations with regard to nitroxide stability as a function of the α-carbon substituent.

Graphical abstract: Synthesis and stability of cyclic α-hydrogen nitroxides

Back to tab navigation

Supplementary files

Publication details

The article was received on 15 Jul 2015, accepted on 20 Aug 2015 and first published on 24 Aug 2015

Article type: Paper
DOI: 10.1039/C5OB01443C
Citation: Org. Biomol. Chem., 2015,13, 10726-10733
  •   Request permissions

    Synthesis and stability of cyclic α-hydrogen nitroxides

    H. Toledo, M. Amar, S. Bar, M. A. Iron, N. Fridman, B. Tumanskii, L. J. W. Shimon, M. Botoshansky and A. M. Szpilman, Org. Biomol. Chem., 2015, 13, 10726
    DOI: 10.1039/C5OB01443C

Search articles by author