The first total synthesis of an anti-leukemic diterpene natural product EBC-329 (1) has been accomplished starting from readily available 6,6-dimethyl-3-oxabicyclo[3.1.0]hexane-2,4-dione (7). An efficient and general approach has been reported for the synthesis of EBC-329 in 13 steps with an overall yield of 10%.
R. S. Thombal and V. H. Jadhav, Org. Biomol. Chem., 2015, 13, 9485 DOI: 10.1039/C5OB01276G
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