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Issue 29, 2015
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A platform for efficient, thiol-stable conjugation to albumin's native single accessible cysteine

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Abstract

Herein we report the use of bromomaleimides for the construction of stable albumin conjugates via conjugation to its native, single accessible, cysteine followed by hydrolysis. Advantages over the classical maleimide approach are highlighted in terms of quantitative hydrolysis and absence of undesirable retro-Michael deconjugation.

Graphical abstract: A platform for efficient, thiol-stable conjugation to albumin's native single accessible cysteine

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Publication details

The article was received on 12 Jun 2015, accepted on 17 Jun 2015 and first published on 17 Jun 2015


Article type: Paper
DOI: 10.1039/C5OB01205H
Citation: Org. Biomol. Chem., 2015,13, 7946-7949
  • Open access: Creative Commons BY license
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    A platform for efficient, thiol-stable conjugation to albumin's native single accessible cysteine

    M. E. B. Smith, M. B. Caspersen, E. Robinson, M. Morais, A. Maruani, J. P. M. Nunes, K. Nicholls, M. J. Saxton, S. Caddick, J. R. Baker and V. Chudasama, Org. Biomol. Chem., 2015, 13, 7946
    DOI: 10.1039/C5OB01205H

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