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Issue 30, 2015
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Rapid optimization of labeled ubiquitinated peptides for monitoring deubiquitinases activities

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Abstract

Studying and targeting deubiquitinases is of high importance due to their various roles in cellular processes and involvement in diseases such as cancer. The recent development of unique probes and reagents using chemical synthesis of proteins became very instrumental in supporting these efforts. Here, we present a protein synthetic approach that enables the rapid synthesis of differently modified labeled-ubiquitinated peptides to facilitate rapid optimization of deubiquitinase substrates.

Graphical abstract: Rapid optimization of labeled ubiquitinated peptides for monitoring deubiquitinases activities

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Publication details

The article was received on 08 Jun 2015, accepted on 02 Jul 2015 and first published on 10 Jul 2015


Article type: Communication
DOI: 10.1039/C5OB01142F
Citation: Org. Biomol. Chem., 2015,13, 8182-8186
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    Rapid optimization of labeled ubiquitinated peptides for monitoring deubiquitinases activities

    S. Ohayon, M. Refua and A. Brik, Org. Biomol. Chem., 2015, 13, 8182
    DOI: 10.1039/C5OB01142F

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