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Issue 31, 2015
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Optimized quinoline amino alcohols as disruptors and dispersal agents of Vibrio cholerae biofilms

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Abstract

The biofilm state is an integral part of the lifecycle of many bacterial pathogens. Identifying inhibitors as molecular probes against bacterial biofilms has numerous potential biomedical applications. Here we report quinoline amino alcohol 20 as a highly potent disruptor of V. cholerae biofilms. Additionally, 20 was able to disperse preformed biofilms, an activity exhibited by few compounds with biofilm inhibiting activity.

Graphical abstract: Optimized quinoline amino alcohols as disruptors and dispersal agents of Vibrio cholerae biofilms

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Publication details

The article was received on 05 Jun 2015, accepted on 30 Jun 2015 and first published on 09 Jul 2015


Article type: Paper
DOI: 10.1039/C5OB01134E
Author version available: Download Author version (PDF)
Citation: Org. Biomol. Chem., 2015,13, 8495-8499
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    Optimized quinoline amino alcohols as disruptors and dispersal agents of Vibrio cholerae biofilms

    B. León, F. P. J. Haeckl and R. G. Linington, Org. Biomol. Chem., 2015, 13, 8495
    DOI: 10.1039/C5OB01134E

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