Issue 32, 2015

PhI(OAc)2-mediated one-pot oxidative decarboxylation and aromatization of tetrahydro-β-carbolines: synthesis of norharmane, harmane, eudistomin U and eudistomin I

Abstract

Iodobenzene diacetate was employed as a mild and efficient reagent for one-pot oxidative decarboxylation of tetrahydro-β-carboline acids and dehydrogenation of tetrahydro-β-carbolines to access the corresponding aromatic β-carbolines. To the best of our knowledge this is the first synthesis of β-carbolines via a one-pot oxidative decarboxylation at ambient temperature. The utility of this protocol has been demonstrated in the synthesis of β-carboline alkaloids norharmane (2o), harmane (2p), eudistomin U (9) and eudistomin I (12).

Graphical abstract: PhI(OAc)2-mediated one-pot oxidative decarboxylation and aromatization of tetrahydro-β-carbolines: synthesis of norharmane, harmane, eudistomin U and eudistomin I

Supplementary files

Article information

Article type
Paper
Submitted
30 Apr 2015
Accepted
26 May 2015
First published
26 May 2015

Org. Biomol. Chem., 2015,13, 8652-8662

Author version available

PhI(OAc)2-mediated one-pot oxidative decarboxylation and aromatization of tetrahydro-β-carbolines: synthesis of norharmane, harmane, eudistomin U and eudistomin I

A. Kamal, Y. Tangella, K. L. Manasa, M. Sathish, V. Srinivasulu, J. Chetna and A. Alarifi, Org. Biomol. Chem., 2015, 13, 8652 DOI: 10.1039/C5OB00871A

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