Issue 26, 2015
From the journal:

Organic & Biomolecular Chemistry

Tanzawaic acids isolated from a marine-derived fungus of the genus Penicillium with cytotoxic activities†

Faviola Cardoso-Martínez,a   José M. de la Rosa,a   Ana R. Díaz-Marrero,‡a   José Darias,a   Claudia Cerella,b   Marc Diederichc  and  Mercedes Cueto*a  

* Corresponding authors

a Instituto de Productos Naturales y Agrobiología del CSIC, Avda. Astrofísico F. Sánchez, 3, 38206 La Laguna, Tenerife, Spain
E-mail: mcueto@ipna.csic.es

b Laboratoire de Biologie Moléculaire et Cellulaire de Cancer, Hôpital Kirchberg, Rue Edward Steichen 9, 2540 Luxembourg, Luxembourg

c College of Pharmacy, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 151-742, Korea

Abstract

Tanzawaic acids M (1), N (2), O (3) and P (4) and the known tanzawaic acids B (5) and E (6), have been isolated from an extract of a cultured marine-derived fungus (strain CF07370) identified as a member of the genus Penicillium. The structures of 1–4 were determined based on spectroscopic evidence. The antimicrobial and cytotoxic activities of compounds 1–6 were evaluated.

Graphical abstract: Tanzawaic acids isolated from a marine-derived fungus of the genus Penicillium with cytotoxic activities

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Article information

DOI
https://doi.org/10.1039/C5OB00773A
Article type
Paper
Submitted
17 Apr 2015
Accepted
20 May 2015
First published
20 May 2015

Org. Biomol. Chem., 2015,13, 7248-7256

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Tanzawaic acids isolated from a marine-derived fungus of the genus Penicillium with cytotoxic activities

F. Cardoso-Martínez, J. M. de la Rosa, A. R. Díaz-Marrero, J. Darias, C. Cerella, M. Diederich and M. Cueto, Org. Biomol. Chem., 2015, 13, 7248 DOI: 10.1039/C5OB00773A

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