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Issue 26, 2015
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Current complexity: a tool for assessing the complexity of organic molecules

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Abstract

Molecular complexity for a synthetic organic chemist is difficult to define, though intuitively known. Despite the importance of this concept, the quantitative assessment of complexity within organic chemistry has remained a challenge. We report here on the development of an approach for generating a unique complexity index, which is reflective of both intrinsic molecular complexity and extrinsic synthetic complexity. This index is based on a community's perception of complexity, within the context of current technology, calculating a molecule's current complexity. Our approach allows for a direct comparison between molecules, the analysis of trends within research programs, it enables an assessment (and comparison) of new synthetic approaches to known molecules and is capable of following a molecule's apparent complexity as it changes over time.

Graphical abstract: Current complexity: a tool for assessing the complexity of organic molecules

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Publication details

The article was received on 08 Apr 2015, accepted on 30 Apr 2015 and first published on 12 May 2015


Article type: Paper
DOI: 10.1039/C5OB00709G
Citation: Org. Biomol. Chem., 2015,13, 7164-7176
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    Current complexity: a tool for assessing the complexity of organic molecules

    J. Li and M. D. Eastgate, Org. Biomol. Chem., 2015, 13, 7164
    DOI: 10.1039/C5OB00709G

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