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Issue 26, 2015
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Cyanine fluorophores for cellular protection against ROS in stimulated macrophages and two-photon ROS detection

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Abstract

We report the first example of a novel two-photon active, biocompatible, and macrophage cell-membrane permeable carbazole-based cyanine fluorophore for the detection of three biologically important ROS, namely, ˙OH, O2 and OCl in solution. This versatile probe shows cellular protection not only in stimulated macrophages from phorbol-12-myristate-13-acetate-induced morphological changes but also lipopolysaccharide-induced cytotoxicity by quenching with the O2 and OCl production, respectively. Such protection could be visualized by a distinct change in the fluorescence intensity of the probe.

Graphical abstract: Cyanine fluorophores for cellular protection against ROS in stimulated macrophages and two-photon ROS detection

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Publication details

The article was received on 01 Apr 2015, accepted on 22 May 2015 and first published on 22 May 2015


Article type: Paper
DOI: 10.1039/C5OB00643K
Author version available: Download Author version (PDF)
Citation: Org. Biomol. Chem., 2015,13, 7307-7312
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    Cyanine fluorophores for cellular protection against ROS in stimulated macrophages and two-photon ROS detection

    M. S. Chan, D. Xu, L. Guo, D. Y. Tam, L. S. Liu, Y. Chen, M. S. Wong and P. K. Lo, Org. Biomol. Chem., 2015, 13, 7307
    DOI: 10.1039/C5OB00643K

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