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Issue 23, 2015
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Ruthenium-catalyzed oxidative coupling of 2-aryl-4-quinazolinones with olefins: synthesis of pyrrolo[2,1-b]quinazolin-9(1H)-one motifs

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Abstract

A ruthenium-catalyzed oxidative coupling of 2-aryl-quinazolinones with olefins via C–H bond activation followed by an intramolecular aza-Michael reaction is described. This strategy allows the direct and efficient construction of pyrrolo[2,1-b]quinazolin-9(1H)-one scaffolds.

Graphical abstract: Ruthenium-catalyzed oxidative coupling of 2-aryl-4-quinazolinones with olefins: synthesis of pyrrolo[2,1-b]quinazolin-9(1H)-one motifs

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Publication details

The article was received on 27 Mar 2015, accepted on 07 May 2015 and first published on 07 May 2015


Article type: Communication
DOI: 10.1039/C5OB00601E
Citation: Org. Biomol. Chem., 2015,13, 6474-6478
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    Ruthenium-catalyzed oxidative coupling of 2-aryl-4-quinazolinones with olefins: synthesis of pyrrolo[2,1-b]quinazolin-9(1H)-one motifs

    Y. Zheng, W. Song, S. Zhang and L. Xuan, Org. Biomol. Chem., 2015, 13, 6474
    DOI: 10.1039/C5OB00601E

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