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Issue 21, 2015
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HIV-1 drug discovery: targeting folded RNA structures with branched peptides

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Abstract

Human immunodeficiency virus type 1 (HIV-1) is an RNA virus that is prone to high rates of mutation. While the disease is managed with current antiretroviral therapies, drugs with a new mode of action are needed. A strategy towards this goal is aimed at targeting the native three-dimensional fold of conserved RNA structures. This perspective highlights medium-sized peptides and peptidomimetics used to target two conserved RNA structures of HIV-1. In particular, branched peptides have the capacity to bind in a multivalent fashion, utilizing a large surface area to achieve the necessary affinity and selectivity toward the target RNA.

Graphical abstract: HIV-1 drug discovery: targeting folded RNA structures with branched peptides

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Publication details

The article was received on 24 Mar 2015, accepted on 28 Apr 2015 and first published on 28 Apr 2015


Article type: Review Article
DOI: 10.1039/C5OB00589B
Citation: Org. Biomol. Chem., 2015,13, 5848-5858
  • Open access: Creative Commons BY-NC license
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    HIV-1 drug discovery: targeting folded RNA structures with branched peptides

    J. E. Wynn and W. L. Santos, Org. Biomol. Chem., 2015, 13, 5848
    DOI: 10.1039/C5OB00589B

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