Issue 16, 2015
From the journal:

Organic & Biomolecular Chemistry

Copper-catalyzed aerobic cascade cycloamination and acyloxylation: a direct approach to 4-acyloxy-1H-pyrazoles†

Zhengwei Ding,a   Qitao Tan,a   Mingchun Gaoa  and  Bin Xu*abc  

* Corresponding authors

a Department of Chemistry, Innovative Drug Research Center, Shanghai University, Shanghai 200444, China
E-mail: xubin@shu.edu.cn
Fax: +86-21-66132830

b State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China

c Shanghai Key Laboratory of Green Chemistry and Chemical Processes, Department of Chemistry, East China Normal University, Shanghai 200062, China

Abstract

A novel direct transformation of hydrazones to acyloxylated pyrazoles by copper-catalyzed regioselective olefinic C(sp2)–H bond cycloamination and acyloxylation was performed under mild conditions, which combines the formation of the pyrazole skeleton and installation of an acyloxyl group in a single step, using facile carboxylic acids as the acyloxylation reagents.

Graphical abstract: Copper-catalyzed aerobic cascade cycloamination and acyloxylation: a direct approach to 4-acyloxy-1H-pyrazoles

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Article information

DOI
https://doi.org/10.1039/C5OB00409H
Article type
Communication
Submitted
28 Feb 2015
Accepted
09 Mar 2015
First published
09 Mar 2015

Org. Biomol. Chem., 2015,13, 4642-4646

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Copper-catalyzed aerobic cascade cycloamination and acyloxylation: a direct approach to 4-acyloxy-1H-pyrazoles

Z. Ding, Q. Tan, M. Gao and B. Xu, Org. Biomol. Chem., 2015, 13, 4642 DOI: 10.1039/C5OB00409H

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