Issue 17, 2015
From the journal:

Organic & Biomolecular Chemistry

Pd-catalyzed enantioselective intramolecular α-arylation of α-substituted cyclic ketones: facile synthesis of functionalized chiral spirobicycles†

Lulu Fan,a   Shinobu Takizawa,*a   Yoshiki Takeuchi,a   Kazuhiro Takenakaa  and  Hiroaki Sasai*a  

* Corresponding authors

a The Institute of Scientific and Industrial Research (ISIR), Osaka University, Mihogaoka, Ibaraki-shi, Osaka 567-0047, Japan
E-mail: taki@sanken.osaka-u.ac.jp
Fax: +81-6-6879-8469
Tel: +81-6-6879-8466

Abstract

Catalytic synthesis of chiral spirocyclic ketones was accomplished via the Pd-catalyzed intramolecular α-arylation of α-substituted cyclic ketones. The obtained spirocyclic ketone could be converted into a bifunctional organocatalyst.

Graphical abstract: Pd-catalyzed enantioselective intramolecular α-arylation of α-substituted cyclic ketones: facile synthesis of functionalized chiral spirobicycles

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Article information

DOI
https://doi.org/10.1039/C5OB00382B
Article type
Communication
Submitted
25 Feb 2015
Accepted
17 Mar 2015
First published
17 Mar 2015

Org. Biomol. Chem., 2015,13, 4837-4840

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Pd-catalyzed enantioselective intramolecular α-arylation of α-substituted cyclic ketones: facile synthesis of functionalized chiral spirobicycles

L. Fan, S. Takizawa, Y. Takeuchi, K. Takenaka and H. Sasai, Org. Biomol. Chem., 2015, 13, 4837 DOI: 10.1039/C5OB00382B

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