We report herein on an accessible protocol for the asymmetric hydroformylation of vinylarenes using formaldehyde as a substitute for syngas. The regioselectivity (branched/linear = up to 96/4) and enantioselectivity (up to 95% ee) can be attributed to the use of chiral Ph-bpe as a ligand.
T. Morimoto, T. Fujii, K. Miyoshi, G. Makado, H. Tanimoto, Y. Nishiyama and K. Kakiuchi, Org. Biomol. Chem., 2015, 13, 4632 DOI: 10.1039/C5OB00378D
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