A stereoselective total synthesis of (−)-cryptocaryol A (1) is described. Key features of the 17-step route include the use of three boron-mediated aldol reaction–reduction sequences to control all stereocenters and an Ando modification of the Horner–Wadsworth–Emmons olefination that permitted the installation of the Z double bond of the α-pyrone ring.
L. C. Dias, P. K. Kuroishi and E. C. de Lucca, Org. Biomol. Chem., 2015, 13, 3575 DOI: 10.1039/C5OB00080G
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