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Issue 10, 2015
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A modular synthesis of functionalised phenols enabled by controlled boron speciation

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Abstract

A modular synthesis of functionalised biaryl phenols from two boronic acid derivatives has been developed via one-pot Suzuki–Miyaura cross-coupling, chemoselective control of boron solution speciation to generate a reactive boronic ester in situ, and oxidation. The utility of this method has been further demonstrated by application in the synthesis of drug molecules and components of organic electronics, as well as within iterative cross-coupling.

Graphical abstract: A modular synthesis of functionalised phenols enabled by controlled boron speciation

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Publication details

The article was received on 14 Jan 2015, accepted on 21 Jan 2015 and first published on 21 Jan 2015


Article type: Paper
DOI: 10.1039/C5OB00078E
Author version available: Download Author version (PDF)
Citation: Org. Biomol. Chem., 2015,13, 3093-3102
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    A modular synthesis of functionalised phenols enabled by controlled boron speciation

    J. J. Molloy, R. P. Law, J. W. B. Fyfe, C. P. Seath, D. J. Hirst and A. J. B. Watson, Org. Biomol. Chem., 2015, 13, 3093
    DOI: 10.1039/C5OB00078E

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