Issue 15, 2015

Palladium-catalyzed α-arylation of carbonyls in the de novo synthesis of aromatic heterocycles

Abstract

Aromatic heterocycles are a very well represented motif in natural products and have found various applications in chemistry and material science, as well as being commonly found in pharmaceutical agents. Thus, new and efficient routes towards this class of compound are always desirable, particularly if they expand the scope of chemical methodology or facilitate more effective pathways to complex substitution patterns. This perspective covers recent developments in the de novo synthesis of aromatic heterocycles via palladium-catalysed α-arylation reactions of carbonyls, which is itself a powerful transformation that has undergone significant development in recent years.

Graphical abstract: Palladium-catalyzed α-arylation of carbonyls in the de novo synthesis of aromatic heterocycles

Article information

Article type
Perspective
Submitted
12 Jan 2015
Accepted
12 Mar 2015
First published
19 Mar 2015
This article is Open Access
Creative Commons BY license

Org. Biomol. Chem., 2015,13, 4367-4373

Author version available

Palladium-catalyzed α-arylation of carbonyls in the de novo synthesis of aromatic heterocycles

H. K. Potukuchi, A. P. Spork and T. J. Donohoe, Org. Biomol. Chem., 2015, 13, 4367 DOI: 10.1039/C5OB00055F

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