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Issue 15, 2015
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Palladium-catalyzed α-arylation of carbonyls in the de novo synthesis of aromatic heterocycles

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Abstract

Aromatic heterocycles are a very well represented motif in natural products and have found various applications in chemistry and material science, as well as being commonly found in pharmaceutical agents. Thus, new and efficient routes towards this class of compound are always desirable, particularly if they expand the scope of chemical methodology or facilitate more effective pathways to complex substitution patterns. This perspective covers recent developments in the de novo synthesis of aromatic heterocycles via palladium-catalysed α-arylation reactions of carbonyls, which is itself a powerful transformation that has undergone significant development in recent years.

Graphical abstract: Palladium-catalyzed α-arylation of carbonyls in the de novo synthesis of aromatic heterocycles

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Publication details

The article was received on 12 Jan 2015, accepted on 12 Mar 2015 and first published on 19 Mar 2015


Article type: Perspective
DOI: 10.1039/C5OB00055F
Citation: Org. Biomol. Chem., 2015,13, 4367-4373
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    Palladium-catalyzed α-arylation of carbonyls in the de novo synthesis of aromatic heterocycles

    H. K. Potukuchi, A. P. Spork and T. J. Donohoe, Org. Biomol. Chem., 2015, 13, 4367
    DOI: 10.1039/C5OB00055F

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