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Issue 13, 2015
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Crispene E, a cis-clerodane diterpene inhibits STAT3 dimerization in breast cancer cells

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Abstract

Crispene E, a new clerodane-type diterpene, inhibited STAT3 dimerization in a cell-free fluorescent polarisation assay and was found to have significant toxicity against STAT3-dependent MDA-MB 231 breast cancer cell line and selectively inhibited the expression of STAT3 and STAT3 target genes cyclin D1, Fascin and bcl-2. Molecular docking studies suggest the molecule inhibits STAT3 by interacting with its SH2 domain. The compound has been isolated from Tinospora crispa and characterized using standard spectroscopic techniques.

Graphical abstract: Crispene E, a cis-clerodane diterpene inhibits STAT3 dimerization in breast cancer cells

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Publication details

The article was received on 10 Jan 2015, accepted on 16 Feb 2015 and first published on 16 Feb 2015


Article type: Communication
DOI: 10.1039/C5OB00052A
Author version available: Download Author version (PDF)
Citation: Org. Biomol. Chem., 2015,13, 3882-3886
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    Crispene E, a cis-clerodane diterpene inhibits STAT3 dimerization in breast cancer cells

    J. Mantaj, S. M. A. Rahman, B. Bokshi, C. M. Hasan, P. J. M. Jackson, R. B. Parsons and K. M. Rahman, Org. Biomol. Chem., 2015, 13, 3882
    DOI: 10.1039/C5OB00052A

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