Issue 9, 2015

Cyclopropanation using flow-generated diazo compounds

Abstract

We have devised a room temperature process for the cyclopropanation of electron-poor olefins using unstabilised diazo compounds, generated under continuous flow conditions. This protocol was applied to a wide range of different diazo species to generate functionalised cyclopropanes which are valuable 3D building blocks.

Graphical abstract: Cyclopropanation using flow-generated diazo compounds

Supplementary files

Article information

Article type
Communication
Submitted
06 Jan 2015
Accepted
06 Jan 2015
First published
07 Jan 2015
This article is Open Access
Creative Commons BY license

Org. Biomol. Chem., 2015,13, 2550-2554

Author version available

Cyclopropanation using flow-generated diazo compounds

N. M. Roda, D. N. Tran, C. Battilocchio, R. Labes, R. J. Ingham, J. M. Hawkins and S. V. Ley, Org. Biomol. Chem., 2015, 13, 2550 DOI: 10.1039/C5OB00019J

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