Issue 7, 2015
From the journal:

Organic & Biomolecular Chemistry

Control of guanine-rich DNA secondary structures depending on the protease activity using a designed PNA peptide†

Kenji Usui,‡*ab   Arisa Okada,‡a   Keita Kobayashia  and  Naoki Sugimoto*ab  

* Corresponding authors

a FIRST (Faculty of Frontiers of Innovative Research in Science and Technology), Konan University, 7-1-20 Minatojima-minamimachi, Chuo-ku, Kobe 650-0047, Japan

b FIBER (Frontier Institute for Biomolecular Engineering Research), Konan University, 7-1-20 Minatojima-minamimachi, Chuo-ku, Kobe 650-0047, Japan
E-mail: kusui@center.konan-u.ac.jp, sugimoto@konan-u.ac.jp
Fax: +81 78 303 1495
Tel: +81 78 303 1418, +81 78 303 1416

Abstract

We constructed a regulation system for DNA secondary structure formation of G-rich sequences using a designed PNA peptide exhibiting an on-to-off switching functionality, depending on the protease activity. This study introduces the new concept of a simple and powerful system for regulating quadruplex-related important biological events.

Graphical abstract: Control of guanine-rich DNA secondary structures depending on the protease activity using a designed PNA peptide

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Article information

DOI
https://doi.org/10.1039/C4OB02535K
Article type
Paper
Submitted
03 Dec 2014
Accepted
04 Dec 2014
First published
18 Dec 2014

Org. Biomol. Chem., 2015,13, 2022-2025

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Control of guanine-rich DNA secondary structures depending on the protease activity using a designed PNA peptide

K. Usui, A. Okada, K. Kobayashi and N. Sugimoto, Org. Biomol. Chem., 2015, 13, 2022 DOI: 10.1039/C4OB02535K

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