Issue 5, 2015
From the journal:

Organic & Biomolecular Chemistry

N-heterocyclic carbene-catalyzed cyclocondensation of 2-aryl carboxylic acids and enones: highly enantioselective synthesis of δ-lactones†

Jin-Tang Cheng,a   Xiang-Yu Chena  and  Song Ye*ab  

* Corresponding authors

a Beijing National Laboratory for Molecular Sciences, Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China
E-mail: songye@iccas.ac.cn
Fax: (+86) 10 6255 4449
Tel: (+86) 10 6264 1156

b National Engineering Research Center for Carbohydrate Synthesis, Jiangxi Normal University, Nanchang 330022, China

Abstract

The enantioselective N-heterocyclic carbene-catalyzed [4 + 2] cyclocondensation of 2-aryl carboxylic acids and enones was developed, affording the corresponding chiral δ-lactones in good yields with good diastereo- and high enantioselectivities.

Graphical abstract: N-heterocyclic carbene-catalyzed cyclocondensation of 2-aryl carboxylic acids and enones: highly enantioselective synthesis of δ-lactones

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Article information

DOI
https://doi.org/10.1039/C4OB02330G
Article type
Communication
Submitted
03 Nov 2014
Accepted
27 Nov 2014
First published
27 Nov 2014

Org. Biomol. Chem., 2015,13, 1313-1316

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N-heterocyclic carbene-catalyzed cyclocondensation of 2-aryl carboxylic acids and enones: highly enantioselective synthesis of δ-lactones

J. Cheng, X. Chen and S. Ye, Org. Biomol. Chem., 2015, 13, 1313 DOI: 10.1039/C4OB02330G

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