We describe the conjugate addition of lithiated difluoromethanephosphonates to a diverse range of nitroglycals as a convenient method for the highly stereoselective synthesis of fluorinated aminoglycosyl phosphonates. Our approach provides opportunities to produce hydrolytically stable mimics of biologically important aminoglycosyl phosphates.
S. Bouwman, R. V. A. Orru and E. Ruijter, Org. Biomol. Chem., 2015, 13, 1317 DOI: 10.1039/C4OB02317J
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