Jump to main content
Jump to site search

Issue 6, 2015
Previous Article Next Article

Divergolide congeners illuminate alternative reaction channels for ansamycin diversification

Author affiliations

Abstract

Isolation and structure elucidation of six new divergolides reveal unusual ansamycin diversification reactions including formation of the unusual isobutenyl side chain from a branched polyketide synthase extender unit, azepinone ring closure, macrolide ring contraction and formation of a seco variant by a neighboring group-assisted decarboxylation.

Graphical abstract: Divergolide congeners illuminate alternative reaction channels for ansamycin diversification

Back to tab navigation

Supplementary files

Publication details

The article was received on 22 Oct 2014, accepted on 25 Nov 2014 and first published on 25 Nov 2014


Article type: Communication
DOI: 10.1039/C4OB02244K
Citation: Org. Biomol. Chem., 2015,13, 1618-1623
  •   Request permissions

    Divergolide congeners illuminate alternative reaction channels for ansamycin diversification

    L. Ding, J. Franke and C. Hertweck, Org. Biomol. Chem., 2015, 13, 1618
    DOI: 10.1039/C4OB02244K

Search articles by author

Spotlight

Advertisements