Issue 6, 2015

Chemoenzymatic flow cascade for the synthesis of protected mandelonitrile derivatives

Abstract

A chemoenzymatic two-step cascade process, with both steps having incompatible reaction conditions, was successfully performed in continuous flow. The chemoenzymatic aqueous formation of cyanohydrins was integrated with a subsequent organic phase protection step in a single flow process utilising a membrane-based phase separation module. The wider applicability of our setup was demonstrated with the synthesis of nine protected cyanohydrin derivatives, all obtained in good yields and high to excellent enantioselectivity.

Graphical abstract: Chemoenzymatic flow cascade for the synthesis of protected mandelonitrile derivatives

Supplementary files

Article information

Article type
Communication
Submitted
05 Oct 2014
Accepted
08 Dec 2014
First published
08 Dec 2014
This article is Open Access
Creative Commons BY license

Org. Biomol. Chem., 2015,13, 1634-1638

Author version available

Chemoenzymatic flow cascade for the synthesis of protected mandelonitrile derivatives

M. M. E. Delville, K. Koch, J. C. M. van Hest and F. P. J. T. Rutjes, Org. Biomol. Chem., 2015, 13, 1634 DOI: 10.1039/C4OB02128B

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