Copper(i)-promoted cycloalkylation–peroxidation of unactivated alkenes via sp3 C–H functionalisation

Abstract

A copper(I)-promoted cycloalkylation–peroxidation strategy has been developed via a three-component reaction involving cycloalkanes, tert-butyl hydroperoxide (TBHP) and internal conjugated alkenes possessing electron-withdrawing groups (EWGs). This process installs C–O and C–C bonds via sp³ C–H functionalisation with concomitant generation of two stereocentres. This regioselective radical addition of coumarin system is opposite to that of styrene.