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Issue 42, 2015
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Responsive polymer brushes for controlled nanoparticle exposure

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Abstract

We propose the design of a novel mixed polymer brush system that could act as a selective sensor with a distinct on–off switch. In the proposed system, a (single) nanoparticle (such as an antibody) is end-attached to a responsive chain, which is surrounded by a brush of nonresponsive chains. The collapse of the responsive chain leads to a protected state, where the nanoparticle is hidden in the polymer brush, while swelling of the responsive chain brings the nanoparticle outside of the brush into an exposed and active state. We investigate this system by numerical self-consistent field theory and predict a first-order like transition between the active state and the protective state at a critical decrease in solvent quality for the responsive chain. We show that by careful design of the brush parameters such as grafting density and chain length, for a given particle size, it is possible to fine-tune the desired switching mechanism.

Graphical abstract: Responsive polymer brushes for controlled nanoparticle exposure

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Publication details

The article was received on 31 Jul 2015, accepted on 28 Sep 2015 and first published on 05 Oct 2015


Article type: Paper
DOI: 10.1039/C5NR05150A
Author version available: Download Author version (PDF)
Citation: Nanoscale, 2015,7, 17871-17878
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    Responsive polymer brushes for controlled nanoparticle exposure

    N. Akkilic, F. A. M. Leermakers and W. M. de Vos, Nanoscale, 2015, 7, 17871
    DOI: 10.1039/C5NR05150A

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