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Issue 23, 2015
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DNA topology influences molecular machine lifetime in human serum

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Abstract

DNA nanotechnology holds the potential for enabling new tools for biomedical engineering, including diagnosis, prognosis, and therapeutics. However, applications for DNA devices are thought to be limited by rapid enzymatic degradation in serum and blood. Here, we demonstrate that a key aspect of DNA nanotechnology—programmable molecular shape—plays a substantial role in device lifetimes. These results establish the ability to operate synthetic DNA devices in the presence of endogenous enzymes and challenge the textbook view of near instantaneous degradation.

Graphical abstract: DNA topology influences molecular machine lifetime in human serum

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Publication details

The article was received on 09 Apr 2015, accepted on 27 Apr 2015 and first published on 30 Apr 2015


Article type: Paper
DOI: 10.1039/C5NR02283E
Citation: Nanoscale, 2015,7, 10382-10390
  • Open access: Creative Commons BY license
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    DNA topology influences molecular machine lifetime in human serum

    S. Goltry, N. Hallstrom, T. Clark, W. Kuang, J. Lee, C. Jorcyk, W. B. Knowlton, B. Yurke, W. L. Hughes and E. Graugnard, Nanoscale, 2015, 7, 10382
    DOI: 10.1039/C5NR02283E

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