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Issue 16, 2015
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Enriched inhibition of cancer and stem-like cancer cells via STAT-3 modulating niclocelles

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Abstract

We describe for the first time a therapeutic strategy to target stem-like cancer cells via STAT-3 modulation using a nanomedicine approach. Niclocelle, a niclosamide loaded rigid core mixed micelle, was synthesized from a self-assembled well-defined amphiphilic diblock copolymer and an FDA-approved signal transducer and activator of transcription factor 3. Followed by a rigorous physico-chemical characterization, niclocelles were evaluated biologically for cytotoxicity and apoptosis in human melanoma (C32) and breast cancer (MDA-MB231 and MCF-7) cells. Niclocelles were found to selectively reduce the CD44+ stem cell population in C32 cells via STAT-3 modulation.

Graphical abstract: Enriched inhibition of cancer and stem-like cancer cells via STAT-3 modulating niclocelles

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Publication details

The article was received on 19 Jan 2015, accepted on 04 Mar 2015 and first published on 05 Mar 2015


Article type: Communication
DOI: 10.1039/C5NR00403A
Citation: Nanoscale, 2015,7, 7127-7132
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    Enriched inhibition of cancer and stem-like cancer cells via STAT-3 modulating niclocelles

    S. K. Misra, T. W. Jensen and D. Pan, Nanoscale, 2015, 7, 7127
    DOI: 10.1039/C5NR00403A

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