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Issue 18, 2015
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Multi-stimuli responsive Cu2S nanocrystals as trimodal imaging and synergistic chemo-photothermal therapy agents

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Abstract

A size and shape tuned, multifunctional metal chalcogenide, Cu2S-based nanotheranostic agent is developed for trimodal imaging and multimodal therapeutics against brain cancer cells. This theranostic agent was highly efficient in optical, photoacoustic and X-ray contrast imaging systems. The folate targeted NIR-responsive photothermal ablation in synergism with the chemotherapeutic action of doxorubicin proved to be a rapid precision guided cancer-killing module. The multi-stimuli, i.e., pH-, thermo- and photo-responsive drug release behavior of the nanoconjugates opens up a wider corridor for on-demand triggered drug administration. The simple synthesis protocol, combined with the multitudes of interesting features packed into a single nanoformulation, clearly demonstrates the competing role of this Cu2S nanosystem in future cancer treatment strategies.

Graphical abstract: Multi-stimuli responsive Cu2S nanocrystals as trimodal imaging and synergistic chemo-photothermal therapy agents

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Publication details

The article was received on 03 Dec 2014, accepted on 28 Feb 2015 and first published on 03 Mar 2015


Article type: Paper
DOI: 10.1039/C4NR07139E
Citation: Nanoscale, 2015,7, 8378-8388
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    Multi-stimuli responsive Cu2S nanocrystals as trimodal imaging and synergistic chemo-photothermal therapy agents

    A. C. Poulose, S. Veeranarayanan, M. S. Mohamed, Y. Nagaoka, R. Romero Aburto, T. Mitcham, P. M. Ajayan, R. R. Bouchard, Y. Sakamoto, Y. Yoshida, T. Maekawa and D. Sakthi Kumar, Nanoscale, 2015, 7, 8378
    DOI: 10.1039/C4NR07139E

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