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Issue 11, 2015
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Manipulating directional cell motility using intracellular superparamagnetic nanoparticles

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Abstract

This study investigated the ability for magnetic nanoparticles to influence cellular migration in the presence of an external magnetic field. We found that the direction of migrating keratinocytes can be controlled and the migration speed of fibroblasts can be increased with the internalisation of these nanoparticles in the presence of a magnetic field. The possibility of shepherding cells towards a region of interest through the use of internalized nanoparticles is an attractive prospect for cell tracking, cell therapies, and tissue engineering applications.

Graphical abstract: Manipulating directional cell motility using intracellular superparamagnetic nanoparticles

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Publication details

The article was received on 08 Nov 2014, accepted on 04 Feb 2015 and first published on 05 Feb 2015


Article type: Communication
DOI: 10.1039/C4NR06594H
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Citation: Nanoscale, 2015,7, 4884-4889
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    Manipulating directional cell motility using intracellular superparamagnetic nanoparticles

    M. Bradshaw, T. D. Clemons, D. Ho, L. Gutiérrez, F. J. Lázaro, M. J. House, T. G. St. Pierre, M. W. Fear, F. M. Wood and K. S. Iyer, Nanoscale, 2015, 7, 4884
    DOI: 10.1039/C4NR06594H

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