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Issue 14, 2015
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Characterizing nanoparticles in complex biological media and physiological fluids with depolarized dynamic light scattering

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Abstract

Light scattering is one of the few techniques available to adequately characterize suspended nanoparticles (NPs) in real time and in situ. However, when it comes to NPs in multicomponent and optically complex aqueous matrices – such as biological media and physiological fluids – light scattering suffers from lack of selectivity, as distinguishing the relevant optical signals from the irrelevant ones is very challenging. We meet this challenge by building on depolarized scattering: Unwanted signals from the matrix are completely suppressed. This approach yields information with an unprecedented signal-to-noise ratio in favour of the NPs and NP-biomolecule corona complexes, which in turn opens the frontier to scattering-based studies addressing the behaviour of NPs in complex physiological/biological fluids.

Graphical abstract: Characterizing nanoparticles in complex biological media and physiological fluids with depolarized dynamic light scattering

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Publication details

The article was received on 06 Nov 2014, accepted on 16 Jan 2015 and first published on 19 Jan 2015


Article type: Paper
DOI: 10.1039/C4NR06538G
Citation: Nanoscale, 2015,7, 5991-5997
  • Open access: Creative Commons BY license
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    Characterizing nanoparticles in complex biological media and physiological fluids with depolarized dynamic light scattering

    S. Balog, L. Rodriguez-Lorenzo, C. A. Monnier, M. Obiols-Rabasa, B. Rothen-Rutishauser, P. Schurtenberger and A. Petri-Fink, Nanoscale, 2015, 7, 5991
    DOI: 10.1039/C4NR06538G

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