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Issue 12, 2015
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Leveraging electrokinetics for the active control of dendritic fullerene-1 release across a nanochannel membrane

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Abstract

General adoption of advanced treatment protocols such as chronotherapy will hinge on progress in drug delivery technologies that provide precise temporal control of therapeutic release. Such innovation is also crucial to future medicine approaches such as telemedicine. Here we present a nanofluidic membrane technology capable of achieving active and tunable control of molecular transport through nanofluidic channels. Control was achieved through application of an electric field between two platinum electrodes positioned on either surface of a 5.7 nm nanochannel membrane designed for zero-order drug delivery. Two electrode configurations were tested: laser-cut foils and electron beam deposited thin-films, configurations capable of operating at low voltage (≤1.5 V), and power (100 nW). Temporal, reproducible tuning and interruption of dendritic fullerene 1 (DF-1) transport was demonstrated over multi-day release experiments. Conductance tests showed limiting currents in the low applied potential range, implying ionic concentration polarization (ICP) at the interface between the membrane's micro- and nanochannels, even in concentrated solutions (≤1 M NaCl). The ability of this nanotechnology platform to facilitate controlled delivery of molecules and particles has broad applicability to next-generation therapeutics for numerous pathologies, including autoimmune diseases, circadian dysfunction, pain, and stress, among others.

Graphical abstract: Leveraging electrokinetics for the active control of dendritic fullerene-1 release across a nanochannel membrane

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Publication details

The article was received on 21 Oct 2014, accepted on 16 Jan 2015 and first published on 19 Jan 2015


Article type: Paper
DOI: 10.1039/C4NR06209D
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Citation: Nanoscale, 2015,7, 5240-5248
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    Leveraging electrokinetics for the active control of dendritic fullerene-1 release across a nanochannel membrane

    G. Bruno, T. Geninatti, R. L. Hood, D. Fine, G. Scorrano, J. Schmulen, S. Hosali, M. Ferrari and A. Grattoni, Nanoscale, 2015, 7, 5240
    DOI: 10.1039/C4NR06209D

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