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Issue 11, 2015
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Complexity in structure-directed prebiotic chemistry. Effect of a defective competing reactant in tetrapyrrole formation

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Abstract

Chemical reactions in prebiotic environments likely entailed complex combinatorial processes with mixtures of reactants. As a case study, the effect of a defective reactant has been examined in a chemical model for the prebiogenesis of tetrapyrrole macrocycles (uroporphyrins). The latter are formed by a multistep process that includes (1) condensation of a β-diketone and an α-aminoketone to form a pyrrole, (2) self-condensation of the pyrrole to form a bilane (tetrapyrromethane), (3) cyclization of the bilane to form a porphyrinogen, and (4) oxidation of the porphyrinogen to form the porphyrin. A defective β-diketone (acetylacetone) affords a pyrrole that can react with nascent oligopyrromethane chains and in so doing terminate chain growth. Quantitative studies show that the porphyrin yield decreases with the fourth power of the mole fraction of the non-defective reactant. Mass spectral examination of the reaction mixture revealed the presence of the pyrrole and of end-capped oligomers derived from the defective diketone. Taken together, the results show the poisoning effect of a small amount of defective reactant in repetitive, irreversible structure-directed reactions, which have been a mainstay in thinking about chemistry leading to the origin of life.

Graphical abstract: Complexity in structure-directed prebiotic chemistry. Effect of a defective competing reactant in tetrapyrrole formation

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Publication details

The article was received on 10 Jun 2015, accepted on 27 Jul 2015 and first published on 11 Aug 2015


Article type: Paper
DOI: 10.1039/C5NJ01474C
Citation: New J. Chem., 2015,39, 8273-8281
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    Complexity in structure-directed prebiotic chemistry. Effect of a defective competing reactant in tetrapyrrole formation

    R. M. Deans, V. Chandrashaker, M. Taniguchi and J. S. Lindsey, New J. Chem., 2015, 39, 8273
    DOI: 10.1039/C5NJ01474C

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