Issue 2, 2015

Fluorescent silica nanoparticles modified chemically with terbium complexes as potential bioimaging probes: their fluorescence and colloidal properties in water

Abstract

It generally requires a complicated reaction protocol for the synthesis of silylated fluorescent lanthanide complexes. In this study, a silylated terbium complex was prepared by a very simple procedure through formation of a Schiff base between a terbium complex bearing a formyl group and 3-aminopropyltriethoxysilane. Using the silylated terbium complex, highly fluorescent silica nanoparticles modified chemically with terbium complexes (Tb-SNPs) were efficiently synthesized by a reverse micelle method with Triton X-100 as a surfactant in cyclohexane. The fluorescence properties of Tb-SNPs were remarkably improved by photostability, pH dependence and fluorescence lifetime, compared to free terbium complexes. Also, Tb-SNPs hardly aggregated under aqueous conditions with different salt concentrations and pHs. From these results, it was found that Tb-SNPs are applicable under physiological aqueous conditions. Furthermore, as an application model, Tb-SNPs were used as the fluorescent label for the imaging of African green monkey kidney cells.

Graphical abstract: Fluorescent silica nanoparticles modified chemically with terbium complexes as potential bioimaging probes: their fluorescence and colloidal properties in water

Supplementary files

Article information

Article type
Paper
Submitted
22 Jul 2014
Accepted
10 Dec 2014
First published
10 Dec 2014

New J. Chem., 2015,39, 1452-1458

Author version available

Fluorescent silica nanoparticles modified chemically with terbium complexes as potential bioimaging probes: their fluorescence and colloidal properties in water

Y. Nakahara, Y. Tatsumi, I. Akimoto, S. Osaki, M. Doi and K. Kimura, New J. Chem., 2015, 39, 1452 DOI: 10.1039/C4NJ01222D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements