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Issue 8, 2015
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Copper(I) targeting in the Alzheimer's disease context: a first example using the biocompatible PTA ligand

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Abstract

Copper(I) coordinating ligands in the Alzheimer's disease context have remained unexplored, despite the biological relevance of this redox state of the copper ion. Here, we show that the PTA ligand can remove copper from Aβ, prevent reactive oxygen species production and oligomer formation, two deleterious events in the disease's etiology.

Graphical abstract: Copper(i) targeting in the Alzheimer's disease context: a first example using the biocompatible PTA ligand

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Publication details

The article was received on 18 Mar 2015, accepted on 09 Apr 2015 and first published on 10 Apr 2015


Article type: Communication
DOI: 10.1039/C5MT00077G
Author version available: Download Author version (PDF)
Citation: Metallomics, 2015,7, 1229-1232
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    Copper(I) targeting in the Alzheimer's disease context: a first example using the biocompatible PTA ligand

    E. Atrián-Blasco, E. Cerrada, A. Conte-Daban, D. Testemale, P. Faller, M. Laguna and C. Hureau, Metallomics, 2015, 7, 1229
    DOI: 10.1039/C5MT00077G

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