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Issue 5, 2015
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Copper intoxication inhibits aerobic nucleotide synthesis in Streptococcus pneumoniae

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Abstract

Copper is universally toxic in excess, a feature exploited by the human immune system to facilitate bacterial clearance. The mechanism of copper intoxication remains unknown for many bacterial species. Here, we demonstrate that copper toxicity in Streptococcus pneumoniae is independent from oxidative stress but, rather, is the result of copper inhibiting the aerobic dNTP biosynthetic pathway. Furthermore, we show that copper-intoxicated S. pneumoniae is rescued by manganese, which is an essential metal in the aerobic nucleotide synthesis pathway. These data provide insight into new targets to enhance copper-mediated toxicity during bacterial clearance.

Graphical abstract: Copper intoxication inhibits aerobic nucleotide synthesis in Streptococcus pneumoniae

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Publication details

The article was received on 08 Jan 2015, accepted on 19 Feb 2015 and first published on 19 Feb 2015


Article type: Paper
DOI: 10.1039/C5MT00011D
Author version available: Download Author version (PDF)
Citation: Metallomics, 2015,7, 786-794
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    Copper intoxication inhibits aerobic nucleotide synthesis in Streptococcus pneumoniae

    M. D. L. Johnson, T. E. Kehl-Fie and J. W. Rosch, Metallomics, 2015, 7, 786
    DOI: 10.1039/C5MT00011D

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