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Issue 5, 2015
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Disruption of zinc and copper interactions with Aβ(1–40) by a non-toxic, isoniazid-derived, hydrazone: a novel biometal homeostasis restoring agent in Alzheimer's disease therapy?

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Abstract

Disruptions of biometal–Aβ(1–40) interactions by an isoniazid-derived hydrazone, INHHQ, were demonstrated via in vitro NMR titrations. The compound has adequate theoretical BBB absorption properties, assessed by in silico studies. In vivo acute toxicity assays indicate that INHHQ is innocuous up to 300 mg kg−1, showing potential as an anti-Alzheimer's drug.

Graphical abstract: Disruption of zinc and copper interactions with Aβ(1–40) by a non-toxic, isoniazid-derived, hydrazone: a novel biometal homeostasis restoring agent in Alzheimer's disease therapy?

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Publication details

The article was received on 03 Jan 2015, accepted on 01 Apr 2015 and first published on 01 Apr 2015


Article type: Communication
DOI: 10.1039/C5MT00003C
Author version available: Download Author version (PDF)
Citation: Metallomics, 2015,7, 743-747
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    Disruption of zinc and copper interactions with Aβ(1–40) by a non-toxic, isoniazid-derived, hydrazone: a novel biometal homeostasis restoring agent in Alzheimer's disease therapy?

    R. A. Hauser-Davis, L. V. de Freitas, D. S. Cukierman, W. S. Cruz, M. C. Miotto, J. Landeira-Fernandez, A. A. Valiente-Gabioud, C. O. Fernández and N. A. Rey, Metallomics, 2015, 7, 743
    DOI: 10.1039/C5MT00003C

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