Issue 4, 2015

Enhancement of exon skipping in mdx52 mice by 2′-O-methyl-2-thioribothymidine incorporation into phosphorothioate oligonucleotides

Abstract

Incorporation of 2′-O-methyl-2-thioribothymidine (s2Tm) into antisense oligoribonucleotides significantly enhanced the exon skipping activity in Duchenne muscular dystrophy model mice.

Graphical abstract: Enhancement of exon skipping in mdx52 mice by 2′-O-methyl-2-thioribothymidine incorporation into phosphorothioate oligonucleotides

Supplementary files

Article information

Article type
Concise Article
Submitted
15 Oct 2014
Accepted
15 Nov 2014
First published
08 Dec 2014

Med. Chem. Commun., 2015,6, 630-633

Author version available

Enhancement of exon skipping in mdx52 mice by 2′-O-methyl-2-thioribothymidine incorporation into phosphorothioate oligonucleotides

Y. Masaki, T. Inde, T. Nagata, J. Tanihata, T. Kanamori, K. Seio, S. Takeda and M. Sekine, Med. Chem. Commun., 2015, 6, 630 DOI: 10.1039/C4MD00468J

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