Jump to main content
Jump to site search

Issue 2, 2015
Previous Article Next Article

Synthetic spirocyclic endoperoxides: new antimalarial scaffolds

Author affiliations

Abstract

Here we report the development of a straightforward synthetic procedure for the preparation of spirocyclic endoperoxides as synthetic analogues of the natural product dihydroplakortin. The peroxides presented here are more potent antiplasmodials than dihydroplakortin itself and we proved for the first time their antimalarial activity in vivo.

Graphical abstract: Synthetic spirocyclic endoperoxides: new antimalarial scaffolds

Back to tab navigation

Supplementary files

Publication details

The article was received on 08 Oct 2014, accepted on 11 Nov 2014 and first published on 12 Nov 2014


Article type: Concise Article
DOI: 10.1039/C4MD00454J
Author version available: Download Author version (PDF)
Citation: Med. Chem. Commun., 2015,6, 357-362
  •   Request permissions

    Synthetic spirocyclic endoperoxides: new antimalarial scaffolds

    M. Brindisi, S. Gemma, S. Kunjir, L. Di Cerbo, S. Brogi, S. Parapini, S. D'Alessandro, D. Taramelli, A. Habluetzel, S. Tapanelli, S. Lamponi, E. Novellino, G. Campiani and S. Butini, Med. Chem. Commun., 2015, 6, 357
    DOI: 10.1039/C4MD00454J

Search articles by author

Spotlight

Advertisements