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Issue 6, 2015
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Why phosphoproteomics is still a challenge

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Abstract

Despite continuous improvements phosphoproteomics still faces challenges that are often neglected, e.g. partially poor recovery of phosphopeptide enrichment, assessment of phosphorylation stoichiometry, label-free quantification, poor behavior during chromatography, and general limitations of peptide-centric proteomics. Here we critically discuss current limitations that need consideration in both qualitative and quantitative studies.

Graphical abstract: Why phosphoproteomics is still a challenge

  • This article is part of the themed collection: Proteomics
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Publication details

The article was received on 10 Jan 2015, accepted on 13 Mar 2015 and first published on 13 Mar 2015


Article type: Opinion
DOI: 10.1039/C5MB00024F
Citation: Mol. BioSyst., 2015,11, 1487-1493
  • Open access: Creative Commons BY-NC license
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    Why phosphoproteomics is still a challenge

    F. A. Solari, M. Dell'Aica, A. Sickmann and R. P. Zahedi, Mol. BioSyst., 2015, 11, 1487
    DOI: 10.1039/C5MB00024F

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