Issue 2, 2015
From the journal:

Molecular BioSystems

A pre-structured helix in the intrinsically disordered 4EBP1†

Do-Hyoung Kim,‡a   Chewook Lee,‡a   Ye-Jin Cho,‡ab   Si-Hyung Lee,a   Eun-Ji Cha,a   Ji-Eun Lim,a   T. Michael Sabo,c   Christian Griesinger,c   Donghan Leec  and  Kyou-Hoon Han*ab  

* Corresponding authors

a Biomedical Translational Research Center, Division of Convergent Biomedical Research, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon, Korea
E-mail: khhan600@kribb.re.kr
Fax: +82 42 860 4259
Tel: +82 42 860 4250

b Department of Bioinformatics, University of Science and Technology (UST), 113 Gwahak-ro, Yuseong-gu, Daejeon, Korea

c Department of NMR-based Structural Biology, Max-Planck Institute for Biophysical Chemistry, Göttingen, Germany

Abstract

The eIF4E–binding protein 1 (4EBP1) has long been known to be completely unstructured without any secondary structures, which contributed significantly to the proposal of the induced fit mechanism for target binding of intrinsically disordered proteins. We show here that 4EBP1 is not completely unstructured, but contains a pre-structured helix.

Graphical abstract: A pre-structured helix in the intrinsically disordered 4EBP1

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C4MB00532E
Article type
Communication
Submitted
05 Sep 2014
Accepted
20 Nov 2014
First published
21 Nov 2014

Mol. BioSyst., 2015,11, 366-369

Permissions

Request permissions

A pre-structured helix in the intrinsically disordered 4EBP1

D. Kim, C. Lee, Y. Cho, S. Lee, E. Cha, J. Lim, T. M. Sabo, C. Griesinger, D. Lee and K. Han, Mol. BioSyst., 2015, 11, 366 DOI: 10.1039/C4MB00532E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Spotlight

Advertisements