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Issue 18, 2015
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Supersoft lithography: candy-based fabrication of soft silicone microstructures

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Abstract

We designed a fabrication technique able to replicate microstructures in soft silicone materials (E < 1 kPa). Sugar-based ‘hard candy’ recipes from the confectionery industry were modified to be compatible with silicone processing conditions, and used as templates for replica molding. Microstructures fabricated in soft silicones can then be easily released by dissolving the template in water. We anticipate that this technique will be of particular importance in replicating physiologically soft, microstructured environments for cell culture, and demonstrate a first application in which intrinsically soft microstructures are used to measure forces generated by fibroblast-laden contractile tissues.

Graphical abstract: Supersoft lithography: candy-based fabrication of soft silicone microstructures

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Publication details

The article was received on 25 Jun 2015, accepted on 29 Jul 2015 and first published on 29 Jul 2015


Article type: Paper
DOI: 10.1039/C5LC00722D
Author version available: Download Author version (PDF)
Citation: Lab Chip, 2015,15, 3760-3765
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    Supersoft lithography: candy-based fabrication of soft silicone microstructures

    C. Moraes, J. M. Labuz, Y. Shao, J. Fu and S. Takayama, Lab Chip, 2015, 15, 3760
    DOI: 10.1039/C5LC00722D

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