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Issue 17, 2015
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Miniaturized, biopsy-implantable chemical sensor with wireless, magnetic resonance readout

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Abstract

Biopsy is an important diagnostic tool for a broad range of conditions. Cancer diagnoses, for example, are confirmed using tissue explanted with biopsy. Here we demonstrate a miniaturized wireless sensor that can be implanted during a biopsy procedure and return chemical information from within the body. Power and readout are wireless via weak magnetic resonant coupling to an external reader. The sensor is filled with responsive nuclear magnetic resonance (NMR) contrast agents for chemical sensitivity, and on-board circuitry constrains the NMR measurement to the contents. This sensor enables longitudinal monitoring of the same location, and its simple readout mechanism is ideal for applications not requiring the spatial information available through imaging techniques. We demonstrated the operation of this sensor by measuring two metabolic markers, both in vitro and in vivo: pH in flowing fluid for over 25 days and in a xenograft tumor model in mice, and oxygen in flowing gas and in a rat hind-limb constriction experiment. The results suggest that this in vivo sensing platform is generalizable to other available NMR contrast agents. These sensors have potential for use in biomedicine, environmental monitoring and quality control applications.

Graphical abstract: Miniaturized, biopsy-implantable chemical sensor with wireless, magnetic resonance readout

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Publication details

The article was received on 14 May 2015, accepted on 09 Jul 2015 and first published on 09 Jul 2015


Article type: Paper
DOI: 10.1039/C5LC00546A
Author version available: Download Author version (PDF)
Citation: Lab Chip, 2015,15, 3465-3472
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    Miniaturized, biopsy-implantable chemical sensor with wireless, magnetic resonance readout

    C. C. Vassiliou, V. H. Liu and M. J. Cima, Lab Chip, 2015, 15, 3465
    DOI: 10.1039/C5LC00546A

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