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Issue 9, 2015
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Design and fabrication of magnetically functionalized flexible micropillar arrays for rapid and controllable microfluidic mixing

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Abstract

Magnetically functionalized PDMS-based micropillar arrays have been successfully designed, fabricated and implanted for controllable microfluidic mixing. The arrangement of PDMS micropillar arrays inside the microchannel can be flexibly controlled by an external magnetic field. As a consequence, the flow fields inside the microchannel can be regulated at will via magnetic activation conveniently. When a microchannel is implanted with such micropillar arrays, two microstreams can be mixed easily and controllably upon the simple application of an on/off magnetic signal. Mixing efficiencies based on micropillar arrays with different densities were investigated and compared. It was found that micropillar arrays with higher density (i.e. smaller pillar pitch) would render better mixing performance. Our microfluidic system is capable of generating highly reproducible results within many cycles of mixing/non-mixing conversion. We believe that the simple mixing–triggering method together with rapid and controllable mixing control will be extraordinarily valuable for various biological or chemical applications in the future.

Graphical abstract: Design and fabrication of magnetically functionalized flexible micropillar arrays for rapid and controllable microfluidic mixing

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Publication details

The article was received on 12 Feb 2015, accepted on 26 Mar 2015 and first published on 26 Mar 2015


Article type: Paper
DOI: 10.1039/C5LC00173K
Author version available: Download Author version (PDF)
Citation: Lab Chip, 2015,15, 2125-2132
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    Design and fabrication of magnetically functionalized flexible micropillar arrays for rapid and controllable microfluidic mixing

    B. Zhou, W. Xu, A. A. Syed, Y. Chau, L. Chen, B. Chew, O. Yassine, X. Wu, Y. Gao, J. Zhang, X. Xiao, J. Kosel, X. Zhang, Z. Yao and W. Wen, Lab Chip, 2015, 15, 2125
    DOI: 10.1039/C5LC00173K

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