Jump to main content
Jump to site search

Issue 1, 2016
Previous Article Next Article

Surfactant technology applied toward an active pharmaceutical ingredient: more than a simple green chemistry advance

Author affiliations

Abstract

During our evaluation of the potential of surfactant technology, we rapidly experienced a straightforward and highly advantageous technology, which we applied on-scale. This resulted into significant benefits across our entire synthetic route, not just from an environmental standpoint but also from an economic and productivity perspective. To name a few: reduction of organic solvent use, reduction of water use, reduction of metric such as PMI, reduction of cost, reduction of cycle time, milder reaction conditions, improved yields, and improved process performances. Quantatively, the differences for some of these virtues approached 50% in favor of surfactant technology, all of which realised in multi-purpose facilities already within the infrastructure of standard pharmaceutical or chemical organizations. All of these benefits were achieved using a catalytic amount of a nonionic designer surfactant (e.g. TPGS-750-M) in water instead of traditional organic solvents.

Graphical abstract: Surfactant technology applied toward an active pharmaceutical ingredient: more than a simple green chemistry advance

Back to tab navigation

Publication details

The article was received on 02 Oct 2015, accepted on 03 Nov 2015 and first published on 09 Nov 2015


Article type: Perspective
DOI: 10.1039/C5GC02371H
Citation: Green Chem., 2016,18, 14-19
  • Open access: Creative Commons BY-NC license
  •   Request permissions

    Surfactant technology applied toward an active pharmaceutical ingredient: more than a simple green chemistry advance

    F. Gallou, N. A. Isley, A. Ganic, U. Onken and M. Parmentier, Green Chem., 2016, 18, 14
    DOI: 10.1039/C5GC02371H

    This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material and it is not used for commercial purposes.

    Reproduced material should be attributed as follows:

    • For reproduction of material from NJC:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
    • For reproduction of material from PCCP:
      [Original citation] - Published by the PCCP Owner Societies.
    • For reproduction of material from PPS:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
    • For reproduction of material from all other RSC journals:
      [Original citation] - Published by The Royal Society of Chemistry.

    Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.

Search articles by author

Spotlight

Advertisements