Issue 7, 2015
From the journal:

Green Chemistry

Copper-catalyzed highly efficient oxidative amidation of aldehydes with 2-aminopyridines in an aqueous micellar system†

Om P. S. Patel,‡a   Devireddy Anand,‡a   Rahul K. Mauryaa  and  Prem P. Yadav*a  

* Corresponding authors

a Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, Lucknow-226031, India
E-mail: pp_yadav@cdri.res.in, ppy_cdri@yahoo.co.in
Fax: +91-522-2771942/2771970
Tel: +91-522-2772450, Ext. 4761

Abstract

An environmentally benign protocol for the synthesis of N-(pyridine-2-yl)amides from aldehydes and 2-aminopyridines has been developed under mild reaction conditions. This approach requires Cu(OTf)2 as a catalyst, and inexpensive molecular iodine as an oxidant under anionic micellar catalysis in aqueous medium at room temperature.

Graphical abstract: Copper-catalyzed highly efficient oxidative amidation of aldehydes with 2-aminopyridines in an aqueous micellar system

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Article information

DOI
https://doi.org/10.1039/C5GC00628G
Article type
Communication
Submitted
24 Mar 2015
Accepted
08 May 2015
First published
08 May 2015

Green Chem., 2015,17, 3728-3732

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Copper-catalyzed highly efficient oxidative amidation of aldehydes with 2-aminopyridines in an aqueous micellar system

O. P. S. Patel, D. Anand, R. K. Maurya and P. P. Yadav, Green Chem., 2015, 17, 3728 DOI: 10.1039/C5GC00628G

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