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Issue 4, 2015
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“On water” catalysis: an expeditious approach for the synthesis of quaternary centered 3-hydroxy-3-(nitromethyl)indolin-2-one derivatives

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Abstract

A novel, efficient, eco-friendly “on water” method has been developed for the Henry reaction of isatins with nitromethane to afford 3-hydroxy-3-nitromethylindolin-2-ones. An enhancement in reaction rate was observed “on water” under mild and catalyst-free conditions. This reaction tolerated a wide range of substrates with good to excellent product yields and is even applicable at large scales. Moreover, this method is environmentally friendly as it reduces the waste generated by the use of toxic solvents.

Graphical abstract: “On water” catalysis: an expeditious approach for the synthesis of quaternary centered 3-hydroxy-3-(nitromethyl)indolin-2-one derivatives

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Publication details

The article was received on 12 Nov 2014, accepted on 02 Feb 2015 and first published on 05 Feb 2015


Article type: Communication
DOI: 10.1039/C4GC02203C
Citation: Green Chem., 2015,17, 2339-2343
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    “On water” catalysis: an expeditious approach for the synthesis of quaternary centered 3-hydroxy-3-(nitromethyl)indolin-2-one derivatives

    P. SaiPrathima, K. Srinivas and M. Mohan Rao, Green Chem., 2015, 17, 2339
    DOI: 10.1039/C4GC02203C

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