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Issue 2, 2015
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Overcoming barriers to green chemistry in the pharmaceutical industry – the Green Aspiration Level™ concept

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Abstract

“Green chemistry” refers to the promotion of safe, sustainable, and waste-minimizing chemical processes. The proliferation of green chemistry metrics without any clear consensus on industry standards is a significant barrier to the adoption of green chemistry within the pharmaceutical industry. We propose the Green Aspiration Level™ (GAL) concept as a novel process performance metric that quantifies the environmental impact of producing a specific pharmaceutical agent while taking into account the complexity of the ideal synthetic process for producing the target molecule. Application of the GAL metric will make possible for the first time an assessment of relative greenness of a process, in terms of waste, versus industry standards for the production process of any pharmaceutical. Our recommendations also include a simple methodology for defining process starting points, which is an important aspect of standardizing measurement to ensure that Relative Process Greenness (RPG) comparisons are meaningful. We demonstrate our methodology using Pfizer's Viagra™ process as an example, and outline aspiration level opportunities for industry and government to dismantle green chemistry barriers.

Graphical abstract: Overcoming barriers to green chemistry in the pharmaceutical industry – the Green Aspiration Level™ concept

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Publication details

The article was received on 12 Aug 2014, accepted on 03 Nov 2014 and first published on 19 Nov 2014


Article type: Perspective
DOI: 10.1039/C4GC01563K
Author version available: Download Author version (PDF)
Citation: Green Chem., 2015,17, 752-768
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    Overcoming barriers to green chemistry in the pharmaceutical industry – the Green Aspiration Level™ concept

    F. Roschangar, R. A. Sheldon and C. H. Senanayake, Green Chem., 2015, 17, 752
    DOI: 10.1039/C4GC01563K

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